Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model.

doi:10.1167/iovs.15-17567

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Article

Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model.

Investigative ophthalmology & visual science - 1 Nov 2015

Kuny Sharee, Cho Woo Jung, Dimopoulos Ioannis S, Sauvé Yves

Abstract excerpt

PURPOSE: We investigated the interplay between photoreceptors expressing mutant ELOVL4 (responsible for Stargardt-like disease, STGD3) and RPE in the initial stages of retinal degeneration. METHODS: Using electron microscopy and electroretinogram (ERG), we assessed RPE and photoreceptor ultrastructure and function in transgenic ELOVL4 (TG1-2 line; TG) and wild-type (WT) littermates. Experiments were done at P30,...

Topics

Animals
Blotting, Western
Cells, Cultured
DNA Mutational Analysis
Disease Models, Animal
Electroretinography
Eye Proteins
Humans
Immunohistochemistry
Macular Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Microscopy, Electron, Transmission

Mutation

RNA

Retinal Pigment Epithelium

Rod Cell Outer Segment

Source

Open in PubMed

Identifiers

PMID: 26529045
DOI: 10.1167/iovs.15-17567

Genes

RPE
ELOVL4
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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