Article
Low immunoglobulin M memory B-cell percentage in patients with heterotaxy syndrome correlates with the risk of severe bacterial infection.
Pediatric research - 1 Feb 2016
Chiu Shuenn-Nan, Shao Pei-Lan, Wang Jou-Kou, Hsu Hui-Wen, Lin Ming-Tai, Chang Luan-Yin, Lu Chun-Yi, Lee Ping-Ing, Huang Li-Min, Wu Mei-Hwan
Abstract excerpt
BACKGROUND: Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI. METHODS: We enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI)...
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