Inherited defects of thyroxine-binding proteins.

doi:10.1016/j.beem.2015.09.002

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Article

Inherited defects of thyroxine-binding proteins.

Best practice & research. Clinical endocrinology & metabolism - 1 Oct 2015

Pappa Theodora, Ferrara Alfonso Massimiliano, Refetoff Samuel

Abstract excerpt

Thyroid hormones (TH) are bound to three major serum transport proteins, thyroxine-binding globulin (TBG), transthyretin (TTR) and human serum albumin (HSA). TBG has the strongest affinity for TH, whereas HSA is the most abundant protein in plasma. Individuals harboring genetic variations in TH transport proteins present with altered thyroid function tests, but are clinically euthyroid and do not require...

Topics

Humans
Hyperthyroxinemia, Familial Dysalbuminemic
Mutation
Thyroid Hormones
Thyroxine-Binding Proteins

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PMID: 26522458
DOI: 10.1016/j.beem.2015.09.002
PMCID: PMC4632647

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