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Article

Thyroxine-binding globulin: organization of the gene and variants.

Hormone research - 1 Jan 1996

Refetoff S, Murata Y, Mori Y, Janssen O E, Takeda K, Hayashi Y

Abstract excerpt

Thyroxine-binding globulin (TBG), the principal thyroid hormone transport protein in human serum, is synthesized by the liver and secreted into the bloodstream as a 54-kD acidic glycoprotein made up of a single polypeptide chain of 395 amino acids and four heterosaccharide units. The carbohydrate chains are important for the correct posttranslational folding, secretion and degradation of the molecule but are not...

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Identifiers

PMID: 8964571
DOI: 10.1159/000184775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Thyroxine-binding globulin: organization of the gene and variants.PMID 8964571Read ↗

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An additional carbohydrate chain in the variant thyroxine-binding globulin-Gary (TBGAsn-96) impairs its secretion.Semantic proximity Read ↗

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Clinical, Biochemical, and Molecular Genetic Characterization of Two Patients with Congenital Hypothyroidism Harboring Novel Compound Heterozygous Variants in the Thyroglobulin GeneSemantic proximity Read ↗

A novel variant in Serpina7 gene in a family with thyroxine-binding globulin deficiency.Semantic proximity Read ↗

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