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Article

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

27 Oct 2015

Abstract excerpt

OBJECTIVE: To determine whether altered IL8 methylation status is associated with increased expression of IL8 in human osteoarthritic (OA) chondrocytes. METHODS: IL8 expression levels and the percentage CpG methylation in human chondrocytes were quantified by qRT-PCR and pyrosequencing in OA patients and in non-OA osteoporotic controls. The effect of CpG methylation on IL8 promoter activity was determined using a...

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PMID: 26521741
DOI: 10.1016/j.joca.2015.02.168

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