Article
HMMvar-func: a new method for predicting the functional outcome of genetic variants.
BMC bioinformatics - 30 Oct 2015
Liu Mingming, Watson Layne T, Zhang Liqing
Abstract excerpt
BACKGROUND: Numerous tools have been developed to predict the fitness effects (i.e., neutral, deleterious, or beneficial) of genetic variants on corresponding proteins. However, prediction in terms of whether a variant causes the variant bearing protein to lose the original function or gain new function is also needed for better understanding of how the variant contributes to disease/cancer. To address this...
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