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Article

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.

Hepatology (Baltimore, Md.) - 1 Feb 2016

Burza Maria Antonella, Motta Benedetta Maria, Mancina Rosellina Margherita, Pingitore Piero, Pirazzi Carlo, Lepore Saverio Massimo, Spagnuolo Rocco, Doldo Patrizia, Russo Cristina, Lazzaro Veronica, Fischer Janett, Berg Thomas, Aghemo Alessio, Cheroni Cristina, De Francesco Raffaele, Fargion Silvia, Colombo Massimo, Datz Christian, Stickel Felix, Valenti Luca, Romeo Stefano

Abstract excerpt

UNLABELLED: Chronic hepatitis C virus (HCV) infection may progress to cirrhosis and hepatocellular carcinoma (HCC). Recently, two genetic variants, DEPDC5 rs1012068 and MICA rs2596542, were associated with the onset of HCC in Asian subjects with chronic HCV infection. The aim of the present study was to analyze whether DEPDC5 and MICA genetic variants were associated with liver disease progression in European...

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Share to Carcinoma, Hepatocellular
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Share to GTPase-Activating Proteins
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Share to Histocompatibility Antigens Class I
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Source

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Identifiers

PMID: 26517016
DOI: 10.1002/hep.28322
PMCID: PMC4737289

Genes

DEPDC5
MICA
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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