Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.

Nature genetics - 3 Jul 2011

Miki Daiki, Ochi Hidenori, Hayes C Nelson, Abe Hiromi, Yoshima Tadahiko, Aikata Hiroshi, Ikeda Kenji, Kumada Hiromitsu, Toyota Joji, Morizono Takashi, Tsunoda Tatsuhiko, Kubo Michiaki, Nakamura Yusuke, Kamatani Naoyuki, Chayama Kazuaki

Abstract excerpt

Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chronic hepatitis C virus (HCV), we analyzed 467,538 SNPs in 212 Japanese individuals with chronic HCV with HCC and 765 individuals with chronic HCV without HCC. We identified one intronic SNP in the DEPDC5 locus on chromosome 22...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier State

Share to Chromosomes, Human, Pair 22

Share to Disease Progression

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Liver Neoplasms

Source

Identifiers

PMID: 21725309
DOI: 10.1038/ng.876

Genes

DEPDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.PMID 21725309Read ↗

Variations in DEPDC5 gene and its association with chronic hepatitis C virus infection in Saudi Arabia.Semantic proximity Read ↗

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.Semantic proximity Read ↗

Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma.Semantic proximity Read ↗

[Hepatitis C virus induced hepatocellular carcinoma associated genes].Semantic proximity Read ↗

Hepatocellular carcinoma: Towards personalized medicineSemantic proximity Read ↗

CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.Semantic proximity Read ↗

Disheveled EGL-10 and pleckstrin domain-containing 5 rs1012068 T/G gene polymorphism among Egyptian chronic HCV-infected patients: disease progression and related complications.Semantic proximity Read ↗

A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanismsSemantic proximity Read ↗

Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease.Semantic proximity Read ↗

New loci associated with chronic hepatitis B virus infection in Han Chinese.Semantic proximity Read ↗

Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.Semantic proximity Read ↗

Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.