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Article

An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis.

RNA (New York, N.Y.) - 1 Dec 2015

Lin Ching-Jung, Smibert Peter, Zhao Xiaoyu, Hu Jennifer F, Ramroop Johnny, Kellner Stefanie M, Benton Matthew A, Govind Shubha, Dedon Peter C, Sternglanz Rolf, Lai Eric C

Abstract excerpt

N(6)-threonylcarbamoyl-adenosine (t6A) is one of the few RNA modifications that is universally present in life. This modification occurs at high frequency at position 37 of most tRNAs that decode ANN codons, and stabilizes cognate anticodon-codon interactions. Nearly all genetic studies of the t6A pathway have focused on single-celled organisms. In this study, we report the isolation of an extensive allelic...

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PMID: 26516084
DOI: 10.1261/rna.053934.115
PMCID: PMC4647464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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