Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia.

Oncotarget - 10 Nov 2015

Bertoli Sarah, Boutzen Helena, David Laure, Larrue Clément, Vergez François, Fernandez-Vidal Anne, Yuan Lingli, Hospital Marie-Anne, Tamburini Jérôme, Demur Cécile, Delabesse Eric, Saland Estelle, Sarry Jean-Emmanuel, Galcera Marie-Odile, Mansat-De Mas Véronique, Didier Christine, Dozier Christine, Récher Christian, Manenti Stéphane

Abstract excerpt

We investigated cell cycle regulation in acute myeloid leukemia cells expressing the FLT3-ITD mutated tyrosine kinase receptor, an underexplored field in this disease. Upon FLT3 inhibition, CDC25A mRNA and protein were rapidly down-regulated, while levels of other cell cycle proteins remained unchanged. This regulation was dependent on STAT5, arguing for FLT3-ITD-dependent transcriptional regulation of CDC25A....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzothiazoles
Share to cdc25 Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Checkpoints

Share to Coculture Techniques

Share to fms-Like Tyrosine Kinase 3

Share to HL-60 Cells

Share to K562 Cells

Share to STAT5 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 26515730
DOI: 10.18632/oncotarget.5706
PMCID: PMC4741984

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia.PMID 26515730Read ↗

STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia.Semantic proximity Read ↗

The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cellsSemantic proximity Read ↗

The cell cycle regulator CDC25A is a target for JAK2V617F oncogeneSemantic proximity Read ↗

Recurrent CDC25C mutations drive malignant transformation in FPD/AML.Semantic proximity Read ↗

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemiaSemantic proximity Read ↗

FLT3-ITD signals for CEBPA and p53 proteolysis by the ubiquitin-proteosome pathwaySemantic proximity Read ↗

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cellsSemantic proximity Read ↗

Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells.Semantic proximity Read ↗

1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2CSemantic proximity Read ↗

The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations.Semantic proximity Read ↗

miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2.Semantic proximity Read ↗

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.