Article
STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia.
Scientific reports - 5 Feb 2020
Sueur Gabrielle, Boutet Alison, Gotanègre Mathilde, Mansat-De Mas Véronique, Besson Arnaud, Manenti Stéphane, Bertoli Sarah
Abstract excerpt
We recently identified the CDC25A phosphatase as a key actor in proliferation and differentiation in acute myeloid leukemia expressing the FLT3-ITD mutation. In this paper we demonstrate that CDC25A level is controlled by a complex STAT5/miR-16 transcription and translation pathway working downstream of this receptor. First, we established by CHIP analysis that STAT5 is directly involved in FLT3-ITD-dependent...
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