Article
Epidermal barrier in hereditary ichthyoses, atopic dermatitis, and psoriasis.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG - 1 Nov 2015
Schmuth Matthias, Blunder Stefan, Dubrac Sandrine, Gruber Robert, Moosbrugger-Martinz Verena
Abstract excerpt
Several skin disorders are associated with impaired skin barrier function. Primary dysfunction is caused by monogenic defects in key components of the epidermis (for example ichthyoses). Secondary barrier impairment occurs in inflammatory dermatoses marked by disturbed epidermal homeostasis (eczema, psoriasis, etc.). In these disorders, inflammation impedes the synthesis or maintenance of skin barrier components....
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