Article
Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.
Molecular genetics and metabolism - 1 Dec 2015
Tekola-Ayele Fasil, Doumatey Ayo P, Shriner Daniel, Bentley Amy R, Chen Guanjie, Zhou Jie, Fasanmade Olufemi, Johnson Thomas, Oli Johnnie, Okafor Godfrey, Eghan Benjami A, Agyenim-Boateng Kofi, Adebamowo Clement, Amoah Albert, Acheampong Joseph, Adeyemo Adebowale, Rotimi Charles N
Abstract excerpt
The metabolic syndrome (MetS) is a constellation of metabolic disorders that increase the risk of developing several diseases including type 2 diabetes and cardiovascular diseases. Although genome-wide association studies (GWAS) have successfully identified variants associated with individual traits comprising MetS, the genetic basis and pathophysiological mechanisms underlying the clustering of these traits...
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