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Article

Notch1 phenotype and clinical stage progression in non-small cell lung cancer.

Journal of hematology & oncology - 6 Feb 2015

Nguyen Dat, Rubinstein Larry, Takebe Naoko, Miele Lucio, Tomaszewski Joseph E, Ivy Percy, Doroshow James H, Yang Sherry X

Abstract excerpt

BACKGROUND: Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene transcriptions. Notch activation has been implicated in tumorigenesis in an i...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25653136
DOI: 10.1186/s13045-014-0104-2
PMCID: PMC4343190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25653136-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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