Article
Notch1 phenotype and clinical stage progression in non-small cell lung cancer.
Journal of hematology & oncology - 6 Feb 2015
Nguyen Dat, Rubinstein Larry, Takebe Naoko, Miele Lucio, Tomaszewski Joseph E, Ivy Percy, Doroshow James H, Yang Sherry X
Abstract excerpt
BACKGROUND: Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene transcriptions. Notch activation has been implicated in tumorigenesis in an increasing number of human malignancies including non-small cell lung cancer (NSCLC). However, Notch1 in distinct...
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