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Article

Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment.

Molecular medicine reports - 1 Dec 2015

Liu Qi, Liu Ping, Ding Yu, Dong Xue-Jun, Wang Zong-Xin, Qian Yan-Er, Wang Qing, Yang Guo-Can

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) have been reported to have important roles in aminoglycoside-induced hearing impairment; however, the underlying molecular mechanisms have remained largely elusive. The current study presented a case of a Chinese patient with maternally inherited aminoglycoside-induced hearing impairment. A profound hearing impairment was identified by clinical evaluation; furthermore,...

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Source

Identifiers

PMID: 26497601
DOI: 10.3892/mmr.2015.4484

Genes

UCN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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