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Article

Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNASer(UCN) genes in two Chinese families.

Biochemical and biophysical research communications - 14 Apr 2006

Zhu Yi, Qian Yaping, Tang Xiaowen, Wang Jindan, Yang Li, Liao Zhisu, Li Ronghua, Ji Jinzhang, Li Zhiyuan, Chen Jianfu, Choo Daniel I, Lu Jianxin, Guan Min-Xin

Abstract excerpt

We report here the clinical, genetic, and molecular characterization of two Chinese families with aminoglycoside induced and non-syndromic hearing impairment. Clinical and genetic evaluations revealed the variable severity and age-of-onset in hearing impairment in these families. Strikingly, there were extremely low penetrances of hearing impairment in these Chinese families. Sequence analysis of the complete...

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PMID: 16500624
DOI: 10.1016/j.bbrc.2006.02.027

Genes

UCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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