Article
Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFNγ- and TNFα-Mediated Antiproliferative Effects and Necroptosis
22 Nov 2016
Abstract excerpt
The clearance of a high-risk human papillomavirus (hrHPV) infection takes time and requires the local presence of a strong type 1 cytokine T cell response, suggesting that hrHPV has evolved mechanisms to resist this immune attack. Using an unique system for non, newly and persistent hrHPV infection, we show that hrHPV infection renders keratinocytes (KCs) resistant to the anti-proliferative and necroptosis...
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