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Article

The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals.

PloS one - 1 Jan 2015

Nishioji Kenichi, Mochizuki Naomi, Kobayashi Masao, Kamaguchi Mai, Sumida Yoshio, Nishimura Takeshi, Yamaguchi Kanji, Kadotani Hiroshi, Itoh Yoshito

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) in non-obese individuals is inadequately elucidated. We aim to investigate the impact of known genetic polymorphisms on NAFLD and the interaction between genetic risks and weight gain on NAFLD in obese and non-obese Japanese individuals. A total of 1164 participants who received health checkups were included. Participants with excessive alcohol consumption, with viral...

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Identifiers

PMID: 26485523
DOI: 10.1371/journal.pone.0140427
PMCID: PMC4617644

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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