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Article

Early in vivo Effects of the Human Mutant Amyloid-β Protein Precursor (hAβPPSwInd) on the Mouse Olfactory Bulb.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Rusznák Zoltán, Kim Woojin Scott, Hsiao Jen-Hsiang T, Halliday Glenda M, Paxinos George, Fu YuHong

Abstract excerpt

The amyloid-β protein precursor (AβPP) has long been linked to Alzheimer's disease (AD). Using J20 mice, which express human AβPP with Swedish and Indiana mutations, we studied early pathological changes in the olfactory bulb. The presence of AβPP/amyloid-β (Aβ) was examined in mice aged 3 months (before the onset of hippocampal Aβ deposition) and over 5 months (when hippocampal Aβ deposits are present). The...

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Identifiers

PMID: 26484907
DOI: 10.3233/JAD-150368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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