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Article

The early stage of bacterial genome-reductive evolution in the host.

PLoS pathogens - 27 May 2010

Song Han, Hwang Junghyun, Yi Hyojeong, Ulrich Ricky L, Yu Yan, Nierman William C, Kim Heenam Stanley

Abstract excerpt

The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence (approximately 3.5 myr), B. mallei provides an excellent resource to study the early steps in bacterial genome reductive evolution in the host. By examining 20...

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PMID: 20523904
DOI: 10.1371/journal.ppat.1000922
PMCID: PMC2877748

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