Article
Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.
Genome research - 1 Jan 2015
Nandi Tannistha, Holden Matthew T G, Holden Mathew T G, Didelot Xavier, Mehershahi Kurosh, Boddey Justin A, Beacham Ifor, Peak Ian, Harting John, Baybayan Primo, Guo Yan, Wang Susana, How Lee Chee, Sim Bernice, Essex-Lopresti Angela, Sarkar-Tyson Mitali, Nelson Michelle, Smither Sophie, Ong Catherine, Aw Lay Tin, Hoon Chua Hui, Michell Stephen, Studholme David J, Titball Richard, Chen Swaine L, Parkhill Julian, Tan Patrick
Abstract excerpt
Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on 106 clinical, animal, and environmental strains from a restricted Asian locale. Whole-genome phylogenies resolved multiple genomic clades of Bp, largely congruent...
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