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Article

Decrease of interleukin (IL)17A gene expression in leucocytes and in the amount of IL-17A protein in CD4+ T cells in children with Down Syndrome.

Pharmacological reports : PR - 1 Dec 2015

Jakubiuk-Tomaszuk Anna, Sobaniec Wojciech, Rusak Małgorzata, Poskrobko Elżbieta, Nędzi Agata, Olchowik Beata, Galicka Anna

Abstract excerpt

BACKGROUND: Down Syndrome is by far the most common and best known chromosomal disorder in humans. It expresses multiple systemic complications with both structural and functional defects as part of the clinical manifestation. The mechanisms of immune changes occurring in Down Syndrome are complex and include an extra gene copy of chromosome 21 and secondary dysregulation of numerous intercellular interactions....

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Identifiers

PMID: 26481531
DOI: 10.1016/j.pharep.2015.04.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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