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Article

Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity.

The Journal of biological chemistry - 1 Jun 2023

Hollander Michael J, Malaker Stacy A, Riley Nicholas M, Perez Idalia, Abney Nayla M, Gray Melissa A, Maxson Julia E, Cochran Jennifer R, Bertozzi Carolyn R

Abstract excerpt

The colony-stimulating factor 3 receptor (CSF3R) controls the growth of neutrophils, the most abundant type of white blood cell. In healthy neutrophils, signaling is dependent on CSF3R binding to its ligand, CSF3. A single amino acid mutation in CSF3R, T618I, instead allows for constitutive, ligand-independent cell growth and leads to a rare type of cancer called chronic neutrophilic leukemia. However, the...

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Identifiers

PMID: 37116708
DOI: 10.1016/j.jbc.2023.104755
PMCID: PMC10245049

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Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity.PMID 37116708Read ↗

A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in LeukemiaSemantic proximity Read ↗

Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor DimerizationSemantic proximity Read ↗

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Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies.Semantic proximity Read ↗

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