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Article

Stimulation of PPARα normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin.

Journal of dermatological science - 1 Nov 2015

Wallmeyer Leonie, Lehnen Dominika, Eger Natascha, Sochorová Michaela, Opálka Lukáš, Kováčik Andrej, Vávrová Kateřina, Hedtrich Sarah

Abstract excerpt

BACKGROUND: Therapeutic options for atopic dermatitis mostly address the symptoms but causal therapies are still missing. Peroxisome proliferator activated receptor (PPAR) agonists exert beneficial effects in patients suffering this disease, whereas the stimulation of PPARα and γ seemed most promising. OBJECTIVES: To elucidate the effects of the PPARα specific agonist WY14643, the PPARγ agonist ciglitazone, and...

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Source

Identifiers

PMID: 26472199
DOI: 10.1016/j.jdermsci.2015.09.012

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ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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