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Article

Genomic analysis of HPV-positive versus HPV-negative oesophageal adenocarcinoma identifies a differential mutational landscape.

Journal of medical genetics - 1 Apr 2016

Rajendra Shanmugarajah, Wang Bin, Merrett Neil, Sharma Prateek, Humphris Jeremy, Lee Hong Ching, Wu Jianmin

Abstract excerpt

BACKGROUND: High-risk human papillomavirus (hr-HPV) has been implicated in a subset of patients with oesophageal adenocarcinoma (OAC). We therefore hypothesised that HPV associated OAC may have distinct genomic aberrations compared with viral negative oesophageal cancer. METHODS: Whole exome sequencing was performed to explore the mutational landscape and potential molecular signature of HPV-positive versus...

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PMID: 26470716
DOI: 10.1136/jmedgenet-2015-103411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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