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Article

Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5.

PloS one - 1 Jan 2015

Takada Shunsuke, Mizuno Keiko, Saito Taro, Asada Akiko, Giese Karl Peter, Hisanaga Shin-Ichi

Abstract excerpt

p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse brain via impaired neuronal migration, which may be relevant for mental retardation in humans. Accordingly, mutations in the p35 gene were reported in patients with...

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Source

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Identifiers

PMID: 26469698
DOI: 10.1371/journal.pone.0140821
PMCID: PMC4607440

Genes

CDK5

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Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5.PMID 26469698Read ↗

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