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Article

Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection.

Malaria journal - 14 Oct 2015

Mendonça Vitor R R, Souza Ligia C L, Garcia Gabriela C, Magalhães Belisa M L, Gonçalves Marilda S, Lacerda Marcus V G, Barral-Netto Manoel

Abstract excerpt

BACKGROUND: Hyperbilirubinaemia (bilirubin >51.3 μmol/L) alone is not indicative of severe malaria, and the immune response underlying hyperbilirubinaemia remains largely unexplored. Liver damage associated with hyperbilirubinaemia may alter the expression of hepcidin, which regulates systemic iron by degrading ferroportin. For this study, the association between hepcidin and the levels of cytokines and...

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Identifiers

PMID: 26466783
DOI: 10.1186/s12936-015-0930-x
PMCID: PMC4607001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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