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Article

Rare inactivating PDE11A variants associated with testicular germ cell tumors.

Endocrine-related cancer - 1 Dec 2015

Pathak Anand, Stewart Douglas R, Faucz Fabio R, Xekouki Paraskevi, Bass Sara, Vogt Aurelie, Zhang Xijun, Boland Joseph, Yeager Meredith, Loud Jennifer T, Nathanson Katherine L, McGlynn Katherine A, Stratakis Constantine A, Greene Mark H, Mirabello Lisa

Abstract excerpt

Germline inactivating mutations of isoform 4 of phosphodiesterase (PDE) 11A (coded by the PDE11A gene) have been associated with familial adrenocortical tumors and familial testicular cancer. Testicular tissue is unique in expressing all four isoforms of PDE11A. In a prior candidate gene study of 94 familial testicular germ cell tumor (TGCT) subjects, we identified a significant association between the presence...

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Share to 3',5'-Cyclic-GMP Phosphodiesterases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Neoplasms, Germ Cell and Embryonal

Share to Phosphoric Diester Hydrolases

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Source

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Identifiers

PMID: 26459559
DOI: 10.1530/ERC-15-0034
PMCID: PMC5812348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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