Article
A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer.
Clinical breast cancer - 1 Apr 2016
Sawyer Michael B, Pituskin Edith, Damaraju Sambasivarao, Bies Robert R, Vos Larissa J, Prado Carla M M, Kuzma Michelle, Scarfe Andrew G, Clemons Mark, Tonkin Katia, Au Heather-Jane, Koski Sheryl, Joy Anil A, Smylie Michael, King Karen, Carandang Diana, Damaraju Vijaya L, Hanson John, Cass Carol E, Mackey John R
Abstract excerpt
BACKGROUND: Epirubicin is metabolized by uridine glucuronosyltransferase 2B7 (UGT2B7), an enzyme rich in single nucleotide polymorphisms (SNPs). We studied whether the -161 C > T germline SNP in UGT2B7 was related to epirubicin metabolism and whether differences exist in the toxicity and efficacy of epirubicin-based chemotherapy among patients who were TT homozygotes, CT heterozygotes, and CC homozygotes....
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