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Article

Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

8 Oct 2015

Abstract excerpt

OBJECTIVE: Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, and cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated with reduced life expectancy and increased prevalence of these age-related diseases. METHODS: We measured telomere length in...

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Share to Growth Hormone and Insulin-like Growth Factors
Share to Pituitary Gland Disorders and Treatments
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PMID: 26448623
DOI: 10.1371/journal.pone.0140189

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