Article
Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients.
BMC immunology - 6 Oct 2015
Piotrowski Wojciech J, Kiszałkiewicz Justyna, Górski Paweł, Antczak Adam, Górski Witold, Pastuszak-Lewandoska Dorota, Migdalska-Sęk Monika, Domańska-Senderowska Daria, Nawrot Ewa, Czarnecka Karolina H, Kurmanowska Zofia, Brzeziańska-Lasota Ewa
Abstract excerpt
BACKGROUND: The chronic course of pulmonary sarcoidosis can lead to lung dysfunction due to fibrosis, in which the signalling pathways TGF-β/Smad and VEGF-A may play a key role. METHODS: We evaluated immunoexpression of TGF-β1, Smad2, 3, and 7, and VEGF-A in serum and bronchoalveolar lavage (BAL) fluid of patients (n = 57) classified according to the presence of lung parenchymal involvement (radiological stage I...
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