Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel

Abstract excerpt

Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease that affects hundreds of millions. Treatment of schistosomiasis depends almost entirely on the drug praziquantel (PZQ). Though essential to treating and controlling schistosomiasis, a major limitation of PZQ is that it is not active against immature mammalian-stage schistosomes. Furthermore, there are reports of field...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Child Nutrition and Water Access
• Share to Parasites and Host Interactions
• Share to Pharmacological Effects and Toxicity Studies