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Rotavirus A-specific single-domain antibodies produced in baculovirus-infected insect larvae are protective in vivo

7 Sept 2012

Abstract excerpt

BACKGROUND: Single-domain antibodies (sdAbs), also known as nanobodies or VHHs, are characterized by high stability and solubility, thus maintaining the affinity and therapeutic value provided by conventional antibodies. Given these properties, VHHs offer a novel alternative to classical antibody approaches. To date, VHHs have been produced mainly in E. coli, yeast, plants and mammalian cells. To apply the...

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PMID: 22953695
DOI: 10.1186/1472-6750-12-59

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