Article
Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.
Respiratory research - 6 Oct 2015
Hackstein Holger, Lippitsch Anne, Krug Philipp, Schevtschenko Inna, Kranz Sabine, Hecker Matthias, Dietert Kristina, Gruber Achim D, Bein Gregor, Brendel Cornelia, Baal Nelli
Abstract excerpt
BACKGROUND: Numerous studies have described the immunosuppressive capacity of mesenchymal stem cells (MSC) but these studies use mixtures of heterogeneous progenitor cells for in vitro expansion. Recently, multipotent MSC have been prospectively identified in murine bone marrow (BM) on the basis of PDFGRa(+) SCA1(+) CD45(-) TER119(-) (PαS) expression but the immunomodulatory capacity of these MSC is unknown....
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