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Article

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

Nucleic acids research - 16 Nov 2015

Ponnusamy Rajesh, Petoukhov Maxim V, Correia Bruno, Custodio Tania F, Juillard Franceline, Tan Min, Pires de Miranda Marta, Carrondo Maria A, Simas J Pedro, Kaye Kenneth M, Svergun Dmitri I, McVey Colin E

Abstract excerpt

Latency-associated nuclear antigen (LANA) is central to episomal tethering, replication and transcriptional regulation of γ2-herpesviruses. LANA binds cooperatively to the terminal repeat (TR) region of the viral episome via adjacent LANA binding sites (LBS), but the molecular mechanism by which LANA assembles on the TR remains elusive. We show that KSHV LANA and MHV-68 LANA proteins bind LBS DNA using strikingly...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26424851
DOI: 10.1093/nar/gkv987
PMCID: PMC4787769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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