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Article

The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA

6 May 2015

Abstract excerpt

Kaposi sarcoma herpesvirus (KSHV) persists as a latent nuclear episome in dividing host cells. This episome is tethered to host chromatin to ensure proper segregation during mitosis. For duplication of the latent genome, the cellular replication machinery is recruited. Both of these functions rely on the constitutively expressed latency-associated nuclear antigen (LANA) of the virus. Here, we report the crystal...

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PMID: 25947153
DOI: 10.1073/pnas.1421804112

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