Article
Obstructive sleep apnoea syndrome and HLA in the North of Portugal.
Revista de neurologia - 1 Oct 2015
Silva Luís, Lopes João, Ramalheira João, Cunha Daniela, Carvalho Cláudia, Bettencourt Andreia, Bras Sandra, Costa Sandra, Silva M Berta, Martins-da-Silva António
Abstract excerpt
INTRODUCTION: The obstructive sleep apnoea syndrome (OSAS) is a common, complex and polygenic disease with diverse aetiologies interacting to produce a single phenotype. OSAS occurs throughout the entire lifespan and familial aggregation has been suggested. Several predisposing factors, as age, gender and obesity have been described. Associations between HLA polymorphisms and sleep disorders are confirmed, in...
Topics
- Cohort Studies
- Female
- Genes, MHC Class I
- Genes, MHC Class II
- Genetic Predisposition to Disease
- Genotype
- HLA Antigens
- HLA-DRB1 Chains
- Humans
- Male
- Obesity