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Article

Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy.

Human molecular genetics - 15 Dec 2015

Pisano Annalinda, Preziuso Carmela, Iommarini Luisa, Perli Elena, Grazioli Paola, Campese Antonio F, Maresca Alessandra, Montopoli Monica, Masuelli Laura, Sadun Alfredo A, d'Amati Giulia, Carelli Valerio, Ghelli Anna, Giordano Carla

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease characterized by degeneration of retinal ganglion cells (RGCs) and consequent optic nerve atrophy. Peculiar features of LHON are incomplete penetrance and gender bias, with a marked male prevalence. Based on the different hormonal metabolism between genders, we proposed that estrogens play a protective role in females and showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26410888
DOI: 10.1093/hmg/ddv396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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