Functional studies of TcRjl, a novel GTPase of Trypanosoma cruzi, reveals phenotypes related with MAPK activation during parasite differentiation and after heterologous expression in Drosophila model system.

doi:10.1016/j.bbrc.2015.09.110

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Article

Functional studies of TcRjl, a novel GTPase of Trypanosoma cruzi, reveals phenotypes related with MAPK activation during parasite differentiation and after heterologous expression in Drosophila model system.

Biochemical and biophysical research communications - 6 Nov 2015

dos-Santos Guilherme Rodrigo Reis Monteiro, Fontenele Marcio Ribeiro, Dias Felipe de Almeida, de Oliveira Pedro Lagerblad, Nepomuceno-Silva José Luciano, de Melo Luiz Dione Barbosa, Araujo Helena Maria Marcolla, Lopes Ulisses Gazos

Abstract excerpt

The life cycle of the protozoan parasite Trypanosoma cruzi comprises rounds of proliferative cycles and differentiation in distinct host environments. Ras GTPases are molecular switches that play pivotal regulatory functions in cell fate. Rjl is a novel GTPase with unknown function. Herein we show that TcRjl blocks in vivo cell differentiation. The forced expression of TcRjl leads to changes in the overall...

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PMID: 26408905
DOI: 10.1016/j.bbrc.2015.09.110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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