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Individual and Combined Effects of CTLA4-CD28 Variants and Oxidant-Antioxidant Status on the Development of Colorectal Cancer.

Anticancer research - 1 Oct 2015

Kucukhuseyin Ozlem, Turan Saime, Yanar Karolin, Arikan Soykan, Duzkoylu Yigit, Aydin Seval, Cakatay Ufuk, Mezani Brunilda, Farooqi Ammad Ahmad, Isitmangil Gulbu Aydinoğlu, Kiran Bayram, Cacina Canan, Yenilmez Ezgi Nurdan, Ergen Arzu, Zeybek Umit, Yaylim Ilhan

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is the third most frequent cancer worldwide. Research has revealed the contributions of the immune system and anti-inflammatory pathways in the development of cancer. The balance between cluster of differentiation 28 (CD28) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) signaling is important for the regulation of immune responses. The oxidant-antioxidant balance by...

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PMID: 26408701

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CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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