Article
Identifying activating mutations in the EGFR gene: prognostic and therapeutic implications in non-small cell lung cancer.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia - 1 Jan 2000
Lopes Gabriel Lima, Vattimo Edoardo Filippo de Queiroz, Castro Junior Gilberto de
Abstract excerpt
Lung cancer is the leading cause of cancer-related deaths worldwide. Promising new therapies have recently emerged from the development of molecular targeted drugs; particularly promising are those blocking the signal transduction machinery of cancer cells. One of the most widely studied cell signaling pathways is that of EGFR, which leads to uncontrolled cell proliferation, increased cell angiogenesis, and...
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