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Article

Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Nov 2014

Jorge S E D C, Kobayashi S S, Costa D B

Abstract excerpt

Lung cancer leads cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC), the most prevalent subtype of this recalcitrant cancer, is usually diagnosed at advanced stages, and available systemic therapies are mostly palliative. The probing of the NSCLC kinome has identified numerous nonoverlapping driver genomic events, including epidermal growth factor receptor (EGFR) gene mutations. This review...

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PMID: 25296354
PMCID: PMC4230282

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EGFR

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