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Article

The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types

23 Sept 2015

Abstract excerpt

Enhancing pre-existing anti-tumor immunity leads to therapeutic benefit for some patients, but why some tumors are more immunogenic than others remains unresolved. We took a unique systems approach to relate patient survival to immune gene expression in >3,500 tumor RNAseq profiles from a dozen tumor types. We found significant links between immune gene expression and patient survival in 8/12 tumor types, with...

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PMID: 26398410
DOI: 10.1371/journal.pone.0138726

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