Article
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
Molecular medicine reports - 1 Nov 2015
Yuan Hongyan, Wang Juan, Wang Fengli, Zhang Nannan, Li Qiongshu, Xie Fei, Chen Tanxiu, Zhai Ruiping, Wang Fang, Guo Yingying, Ni Weihua, Tai Guixiang
Abstract excerpt
Mucin 1 (MUC1) is an oncogene that has a crucial role in the pathogenesis and progression of the majority of epithelial malignant tumors. Our previous study demonstrated that MUC1 gene silencing inhibited the growth of SMMC‑7721 cells in vitro and in vivo, however, whether this growth inhibition is associated with apoptotic cell death remains to be elucidated. In the present study, it was found that MUC1 gene...
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