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Article

Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD.

Journal of child psychology and psychiatry, and allied disciplines - 1 Apr 2016

van Goozen Stephanie H M, Langley Kate, Northover Clare, Hubble Kelly, Rubia Katya, Schepman Karen, O'Donovan Michael C, Thapar Anita

Abstract excerpt

BACKGROUND: There is a known strong genetic contribution to aggression in those with ADHD. In a previous investigation of a large population cohort, impaired 'emotional/social cognitive' processing, assessed by questionnaire, was observed to mediate the link between COMT Val158Met and aggression in individuals with ADHD. We set out to replicate and extend this finding in a clinical sample, using task-based and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inhibition, Psychological

Source

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Identifiers

PMID: 26395975
DOI: 10.1111/jcpp.12464
PMCID: PMC5102627

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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