Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry.

doi:10.1007/s10620-015-3859-6

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Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry.

Digestive diseases and sciences - 1 Jan 2016

Zamudio Roxana, Pereira Latife, Rocha Carolina D, Berg Douglas E, Muniz-Queiroz Thaís, Sant Anna Hanaisa P, Cabrera Lilia, Combe Juan M, Herrera Phabiola, Jahuira Martha H, Leão Felipe B, Lyon Fernanda, Prado William A, Rodrigues Maíra R, Rodrigues-Soares Fernanda, Santolalla Meddly L, Zolini Camila, Silva Aristóbolo M, Gilman Robert H, Tarazona-Santos Eduardo, Kehdy Fernanda S G

Abstract excerpt

BACKGROUND: Gastric adenocarcinoma is associated with chronic infection by Helicobacter pylori and with the host inflammatory response triggered by it, with substantial inter-person variation in the immune response profile due to host genetic factors. AIM: To investigate the diversity of the proinflammatory genes IL8, its receptors and PTGS2 in Amerindians; to test whether candidate SNPs in these genes are...

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PMID: 26391267
DOI: 10.1007/s10620-015-3859-6

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PTGS2
FOXO3
TNF

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