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Article

First report of somatic mosaicism for mutations in STK11 in four patients with Peutz-Jeghers syndrome.

Familial cancer - 1 Jan 2016

McKay Victoria, Cairns Diane, Gokhale David, Mountford Roger, Greenhalgh Lynn

Abstract excerpt

Peutz-Jeghers syndrome (PJS) is an autosomal dominant cancer predisposition syndrome characterised by gastrointestinal polyposis and mucocutaneous pigmentation. Mutations in STK11, a serine-threonine protein kinase, have been associated with PJS in up to 100 % of published series. The hypothesis that a further genetic locus for PJS exists is controversial. No mutations in any other genes have been described in...

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Source

Identifiers

PMID: 26386697
DOI: 10.1007/s10689-015-9839-3

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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First report of somatic mosaicism for mutations in STK11 in four patients with Peutz-Jeghers syndrome.PMID 26386697Read ↗

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