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In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects

4 Mar 2025

Abstract excerpt

In vitro fertilization (IVF) is a noncoital method of conception used to treat human infertility. Although IVF is viewed as largely safe, it is associated with adverse outcomes in the fetus, placenta, and adult offspring. Because studies focusing on the effect of IVF on the male reproductive system are limited, we used a mouse model to assess the morphological and molecular effects of IVF on male offspring. We...

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PMID: 40036079
DOI: 10.1172/jci.insight.188931

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