Article
Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.) - 1 Dec 2015
Zhao Jian, Wu Hui, Langefeld Carl D, Kaufman Kenneth M, Kelly Jennifer A, Bae Sang-Cheol, Alarcón Graciela S, Anaya Juan-Manuel, Criswell Lindsey A, Freedman Barry I, Kamen Diane L, Gilkeson Gary S, Jacob Chaim O, James Judith A, Merrill Joan T, Gaffney Patrick M, Sivils Kathy Moser, Niewold Timothy B, Petri Michelle A, Song Seung Taek, Jeong Hye-Jin, Ramsey-Goldman Rosalind, Reveille John D, Scofield R Hal, Stevens Anne M, Boackle Susan A, Vilá Luis M, Chang Deh-Ming, Song Yeong Wook, Vyse Timothy J, Harley John B, Brown Elizabeth E, Edberg Jeffrey C, Kimberly Robert P, Hahn Bevra H, Grossman Jennifer M, Tsao Betty P, La Cava Antonio
Abstract excerpt
Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA...
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