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Article

Multiplex genotyping based on the melting temperature of a single locked nucleic acid probe.

Analytical biochemistry - 15 Dec 2015

Ahn Jeong Jin, Kim Ji-Hoon, Kim Youngjoo, Hong Ji Young, Kim Gi Won, Hwang Seung Yong

Abstract excerpt

Locked nucleic acid (LNA) is a modified RNA nucleotide that can be incorporated at specific positions to generate probes with the desired length, melting temperature (TM), and specificity. Here, we describe a method of multiplex genotyping based on dramatic shifts in the TM of a single dual-labeled LNA probe. Using this method, two varieties of the hairtail fish Trichiurus lepturus can be distinguished from each...

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PMID: 26384644
DOI: 10.1016/j.ab.2015.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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